Lotto may refer to:
- Lotto, original, 15th century name of the Italian lottery
- Lotto America, one of many U.S. lottery games called Lotto
- Lotto, a railway station in Milan, Italy
- Lotto carpet, a carpet having a lacy arabesque pattern
- Lotto Sport Italia, an Italian sports apparel manufacturer
- Lotto–Dstny, a Belgian cycling team
- "Lotto" , a 2011 episode of the US television series
- Lotto (band), a Polish alternative rock trio
- Lotto (album), by EXO
- "Lotto" (song), by EXO
- "Lotto", a song by Joyner Lucas from the 2020 album ADHD
- Lorenzo Lotto, Italian painter, draughtsman and illustrator
- Myron P. Lotto (1925–2017), American politician
