Secco is a surname of Italian origin, which means dry. It may refer to:
- Alessio Secco, Italian football manager
- Caio Secco, Brazilian footballer
- Deborah Secco, Brazilian actress
- Edson Secco, Brazilian composer, musician, and sound designer
- Louis Secco (1927–2008), Canadian ice hockey player and Olympic medalist
- Madeline Secco, Canadian women's field hockey player
- Stefano Secco, Italian operatic tenor
- Tom Secco (born ?), American men's soccer coach
