Saffo may refer to:
- Saffo (Mayr), 1794 opera by Mayr
- Saffo (Pacini), 1840 opera by Pacini
- Saffo in Leucade, by Francesco Morlacchi (1784-1841)
- Paul Saffo, American technology forecaster
- Saffo the Greek, American organised crime figure, early 20th century
- Saffo Music, 1977 album by Lara Saint Paul
- Bill Saffo, Mayor of Wilmington, North Carolina
