Sob is a verb meaning cry. Sob and SoB may refer to:
- Souls on Board, used in Aviation communication
- Seventeen or Bust, a distributed computing project
- Special Operations Battalion (SOB), an elite unit of the Croatian army
- Society of Old Brooklynites
- Son of a bitch, an insult or curse phrase, sometimes abbreviated as "S.O.B."
- Sons of Ben
- Suggested opening bid, a term in auctioneering
- Super Oralloy Bomb, a nuclear bomb
- Senate Office Building
- Dirksen Senate Office Building
- Russell Senate Office Building
- Hart Senate Office Building
- S.O.B. Hill, a mountain in Utah, United States
- Start of business, the start of the business day
- Sulfur-oxidizing bacteria, participating to the sulfur cycle
