The Nexus for Exoplanet System Science (NExSS) initiative is a National Aeronautics and Space Administration (NASA) virtual institute designed to foster interdisciplinary collaboration in the search for life on exoplanets. Led by the Ames Research Center, the NASA Exoplanet Science Institute, and the Goddard Institute for Space Studies, NExSS will help organize the search for life on exoplanets from participating research teams and acquire new knowledge about exoplanets and extrasolar planetary systems.