Monergism is the view in Christian theology which holds that the Holy Spirit is the only agent that effects the regeneration of Christians. It is contrasted with synergism; the view that there is a cooperation between the divine and the human in the regeneration process. It is most often associated with Lutheranism, as well as with the Reformed tradition and its doctrine of irresistible grace, and particularly with historical doctrinal differences between Calvinism and Arminianism.