Manc or MANC may refer to:
- Something pertaining to the city of Manchester, in North West England
- The Manchester dialect, or Manc accent, spoken in Manchester and outlying areas
- A derogatory term for either Manchester City F.C. or Manchester United F.C.
- ManC (magazine), a magazine about Manchester City F.C.
- The Manc, the people's voice of Greater Manchester
- The MidAmerica Nazarene University, sometimes abbreviated to MANC
- The Cameroonian National Action Movement, known by its French acronym MANC
- An Istanbul based designer accessories brand mainly focusing on leather goods.
