MacManus is a family name that may refer to:
- Annie MacManus – Irish DJ and television presenter
- Arthur MacManus (1889–1927) – Scottish trade unionist, political activist
- Diana MacManus – US athlete in swimming
- Dony MacManus – Irish sculptor, educator
- Emily MacManus (1886–1978) – Irish nurse, OBE recipient
- Declan MacManus – English musician, singer and songwriter
- Francis MacManus (1909–1965) – Irish novelist
- Henry MacManus – Irish painter
- Joseph MacManus (1970–1992) – member in the Sligo Brigade of the Provisional Irish Republican Army
- Rosina MacManus – Irish supporter of Camogie Association
- Ross MacManus (1927–2011) – British musician
- Seán MacManus (politician) – Irish political figure, father of Joseph MacManus
- Seumas MacManus (1869–1960) – Irish author, dramatist, poet
- Steve MacManus – British comic writer, author, editor
- Terence MacManus – Irish rebel
- Theodore F. MacManus (1872–1940) – US advertisingman
- Tristan MacManus – Irish dancer
