MNE, mne or MnE may mean:
- Ministry of Foreign Affairs (Portugal), the Portuguese foreign affairs ministry
- MNE, the international vehicle registration code and ISO 3166-1 alpha-3 country code for Montenegro
- MNE, the National Rail station code for Manea railway station, Fenland, Cambridgeshire, England
- mne, the ISO 639-2 code for the Naba language
- Modern English (MnE), the form of the language spoken from roughly 1550 to the present
- Multinational enterprise, a multinational corporation
