Lykke is a surname. Notable people with the surname include:
- Anne Lykke (1595–1641), Danish noblewoman and royal mistress of Christian, Prince Elect of Denmark
- Ivar Lykke (politician) (1872–1949), Norwegian politician; Prime Minister of Norway, 1926–1928
- Ivar Lykke (footballer) (1889–1955), Danish amateur footballer
- Ivar Lykke (architect), Norwegian architect
- Lykke Li, Swedish singer-songwriter
- Nina Lykke, Swedish professor of gender studies at Linköping University
- Sophie Lykke, Danish county administrator, landholder and noble
