KSIX may refer to:
- KSIX (AM), a radio station licensed to serve Corpus Christi, Texas, United States
- KSIX-TV, a television station licensed to serve Hilo, Hawaii, United States
- KFVE, a television station licensed to serve Kailua-Kona, Hawaii, which held the call sign KSIX-TV in 2020
- KZTV, a television station licensed to serve Corpus Christi, Texas, which held the call sign KSIX-TV from 1956 to 1957
