IPSC may refer to:
- International Practical Shooting Confederation, a shooting sport association based on the concept of practical shooting
- Ispahani Public School & College, a school in Chittagong, Bangladesh
- Institute for the Protection and Security of the Citizen, located in Ispra, Italy, is one of the seven institutes of the Joint Research Centre, a Directorate-General of the European Commission
- Internet Problem Solving Contest, an online programming competition
- IP Site Connect, a feature of digital mobile radio (DMR)
- Independent Parliamentary Standards Commission
