HSF may refer to:
- Hazara Student Federation, in Pakistan
- Heat shock factor, a protein transcription factor
- Hellenic Sailing Federation, Greece
- Herbert Smith Freehills, a law firm
- Hispanic Scholarship Fund
- Home Service Force, of the British Army
- Homer Stryker Field, a stadium in Kalamazoo, Michigan, United States
- Houston Shakespeare Festival, Texas, US
- Human Social Functioning
- IATA code of Suifenhe Airport
