Duane may refer to:
- Duane
- Duane (surname)
- Duane, New York, a US town
- the title character of Duane Hopwood, a 2005 film featured in the Sundance Film Festival
- Duane Adelier, a main character of Unsounded, a 2012 fantasy adventure graphic novel
- USCGC Duane (WPG-33), a US Coast Guard cutter and artificial-reef shipwreck
