Centinela may refer to:
- El Centinela, a mountain west of Mexicali, Baja California, Mexico
- La Centinela, an archaeological site in the Chincha Valley of Peru
- Centinela Avenue, major street in the Westside region of Los Angeles County, California
- Centinela Creek, Los Angeles County, California
- Centinela Springs, a historic artesian spring
- El Centinela, the Spanish-language version of the Catholic Sentinel
- California State Prison, Centinela
